![]() Benzodiazepines, in particular lorazepam, midazolam and diazepam. For more details about poisoning in Florida, see the Florida. medications for the treatment of amphetamine-induced psychosis. "Hyperthermia can be life threatening and should be managed aggressively with sedation plus evaporative cooling, ice packs, and maintenance of intravascular volume and urine flow with IV normal saline solution. A large percentage of people who die from poisoning have combined multiple drugs with alcohol. ?-Blockers (eg, metoprolol 2 to 5 mg IV) may be used for severe ventricular arrhythmias or tachycardia. Hypertension that does not respond to benzodiazepines is treated with nitrates (occasionally nitroprusside or other antihypertensives as needed, depending on the severity of the hypertension. ![]() Propofol, with mechanical ventilation, may be required for severe agitation. High doses or a continuous infusion may be required. Lorazepam 2 to 3 mg IV q 5 min titrated to effect may be used. Overdose can be intentional in suicidal patients accidental in combination with other central nervous system (CNS) depressants, such as alcohol and opioids, and in older people and occasionally by medication error. "Benzodiazepines are the preferred initial treatment for CNS excitation, seizures, tachycardia, and hypertension. Benzodiazepines (BZDs) are the most commonly prescribed medications for anxiety, sedation, and sleep. Urinary acidification hastens amphetamine excretion, but it may worsen myoglobin precipitation in the renal tubules and thus is not recommended. "When significant oral toxicity is recent (eg, < 1 to 2 h), activated charcoal may be given to limit absorption, although this intervention has not been shown to reduce morbidity or mortality.
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